{"id":2177,"date":"2024-10-15T12:42:41","date_gmt":"2024-10-15T11:42:41","guid":{"rendered":"https:\/\/www.oldpharma.it\/%e9%98%bf%e7%b1%b3%e5%8d%a1%e6%98%9f%ef%bc%9a%e4%bd%9c%e7%94%a8%e6%9c%ba%e5%88%b6%e5%92%8c%e6%8a%97%e7%94%9f%e7%b4%a0%e8%80%90%e8%8d%af%e6%80%a7%e8%af%84%e4%bc%b0\/"},"modified":"2024-10-15T12:43:29","modified_gmt":"2024-10-15T11:43:29","slug":"amikacin-mechanism-of-action-and-antibiotic-resistance-evaluations-cn","status":"publish","type":"post","link":"https:\/\/www.oldpharma.it\/zh-hant\/amikacin-mechanism-of-action-and-antibiotic-resistance-evaluations-cn\/","title":{"rendered":"\u963f\u7c73\u5361\u661f\uff1a\u4f5c\u7528\u673a\u5236\u548c\u6297\u751f\u7d20\u8010\u836f\u6027\u8bc4\u4f30"},"content":{"rendered":"\n

\u963f\u7c73\u5361\u661f\u662f\u4e00\u79cd\u5c5e\u4e8e\u6c28\u57fa\u7cd6\u82f7\u7c7b\u7684\u6297\u751f\u7d20\uff0c\u4ee5\u6cbb\u7597\u9769\u5170\u6c0f\u9634\u6027\u83cc\u5f15\u8d77\u7684\u4e25\u91cd\u611f\u67d3\u800c\u95fb\u540d\u3002\u5728\u75c5\u539f\u4f53\u5bf9\u5176\u4ed6\u6297\u751f\u7d20\uff08\u5982\u5e86\u5927\u9709\u7d20\u548c\u03b2-\u5185\u9170\u80fa\u7c7b\uff09\u4ea7\u751f\u8010\u836f\u6027\u7684\u60c5\u51b5\u4e0b\uff0c\u8fd9\u79cd\u836f\u7269\u7ecf\u5e38\u88ab\u4f7f\u7528\uff0c\u662f\u5bf9\u6297\u6297\u751f\u7d20\u8010\u836f\u6027\u7684\u91cd\u8981\u8d44\u6e90\u3002\u7136\u800c\uff0c\u4e0e\u4efb\u4f55\u6297\u751f\u7d20\u6cbb\u7597\u4e00\u6837\uff0c\u4f7f\u7528\u8fd9\u79cd\u836f\u7269\u9700\u8981\u5c0f\u5fc3\u8c28\u614e\uff0c\u4ee5\u5e73\u8861\u7597\u6548\u548c\u6f5c\u5728\u7684\u526f\u4f5c\u7528\u3002<\/p>\n\n

\u6839\u636e\u4e00\u4e9b\u79d1\u5b66\u7814\u7a76\uff0c\u5305\u62ec \u201cAR-ISS 2022 \u5e74\u62a5\u544a \u201d\u548c\u7531 P. G. Gooding\u3001E. Berman\u3001A. Z. Lane \u548c K. Agre \u7b7e\u7f72\u7684\u6587\u7ae0 \u201c\u963f\u7c73\u5361\u661f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u7efc\u8ff0\u201d\uff08\u8fd9\u662f\u6709\u5173\u8be5\u4e3b\u9898\u7684\u4e24\u9879\u6700\u5168\u9762\u548c\u6700\u6743\u5a01\u7684\u7814\u7a76\uff09\uff0c\u6211\u4eec\u6ce8\u610f\u5230\u963f\u7c73\u5361\u661f\u662f\u5f53\u4eca\u7597\u6548\u6700\u597d\u7684\u836f\u7269\u3002Agre \u7684\u6587\u7ae0 \u201c\u963f\u7c73\u5361\u661f\u4e34\u5e8a\u8bd5\u9a8c\u7ed3\u679c\u7efc\u8ff0\u201d\uff08\u8fd9\u662f\u8fd9\u65b9\u9762\u6700\u5168\u9762\u3001\u6700\u6743\u5a01\u7684\u4e24\u9879\u7814\u7a76\uff09\uff0c\u6211\u4eec\u6ce8\u610f\u5230\uff0c\u4e0e\u5176\u4ed6\u5e38\u7528\u7684\u6cbb\u7597\u7ec6\u83cc\u611f\u67d3\u7684\u836f\u7269\u76f8\u6bd4\uff0c\u963f\u7c73\u5361\u661f\u662f\u76ee\u524d\u5728\u6cbb\u6108\u7387\u65b9\u9762\u7597\u6548\u6700\u597d\u3001\u6297\u751f\u7d20\u8010\u836f\u6027\u6c34\u5e73\u6700\u4f4e\u7684\u836f\u7269\u3002<\/p>\n\n

\"阿米卡星\"<\/figure>\n\n

\u4f5c\u7528\u673a\u5236<\/h2>\n\n

\u963f\u7c73\u5361\u661f\u901a\u8fc7\u6291\u5236\u7ec6\u83cc\u86cb\u767d\u8d28\u5408\u6210\u53d1\u6325\u4f5c\u7528\u3002\u5b83\u5e72\u6270\u80bd\u7684\u5f62\u6210\uff0c\u5bfc\u81f4\u4ea7\u751f\u5f02\u5e38\u86cb\u767d\u8d28\uff0c\u635f\u5bb3\u7ec6\u83cc\u7684\u91cd\u8981\u529f\u80fd\u3002\u8fd9\u79cd\u673a\u5236\u4f1a\u7834\u574f\u8d28\u819c\uff0c\u5bfc\u81f4\u94be\u6d41\u5931\uff0c\u6700\u7ec8\u5bfc\u81f4\u7ec6\u80de\u89e3\u4f53\u3002\u8fd9\u79cd\u4f5c\u7528\u5bf9\u9769\u5170\u6c0f\u9634\u6027\u83cc\u5982\u94dc\u7eff\u5047\u5355\u80de\u83cc\uff08\u6211\u4eec\u5c06\u5728\u4e0b\u4e00\u8282\u8ba8\u8bba\uff09\u3001\u6c99\u96f7\u6c0f\u83cc\u3001\u53d8\u5f62\u6746\u83cc\u3001\u514b\u96f7\u4f2f\u6c0f\u83cc\u3001\u80a0\u6746\u83cc\u548c\u5927\u80a0\u6746\u83cc\u7279\u522b\u6709\u6548\uff0c\u5c24\u5176\u662f\u5f53\u8fd9\u4e9b\u7ec6\u83cc\u5bf9\u5176\u4ed6\u6c28\u57fa\u7cd6\u82f7\u7c7b\u836f\u7269\u4ea7\u751f\u6297\u836f\u6027\u65f6\u3002<\/p>\n\n

\u963f\u7c73\u5361\u661f\u7684\u4e34\u5e8a\u7597\u6548<\/h2>\n\n

\u4e00\u9879\u5728 10 \u4e2a\u56fd\u5bb6\u5bf9 1 098 \u540d\u60a3\u8005\u8fdb\u884c\u7684\u7814\u7a76\u8868\u660e\uff0c\u5728\u7b26\u5408\u836f\u7269\u7597\u6548\u8bc4\u4f30\u6761\u4ef6\u7684 697 \u540d\u60a3\u8005\u4e2d\uff0c\u963f\u7c73\u5361\u661f\u4f7f 81% \u7684\u60a3\u8005\u75ca\u6108\u3002\u8fd9\u4e00\u7ed3\u679c\u662f\u901a\u8fc7\u4e34\u5e8a\u7f13\u89e3\u548c\u6839\u9664\u611f\u67d3\u75c5\u539f\u4f53\u89c2\u5bdf\u5230\u7684\u3002\u6ccc\u5c3f\u751f\u6b96\u7cfb\u7edf\u611f\u67d3\u7684\u7597\u6548\u6700\u597d\uff0c\u6709\u6548\u7387\u8fbe 90%\uff0c\u5176\u6b21\u662f\u5316\u8113\u6027\u611f\u67d3\uff0885%\uff09\u548c\u76ae\u80a4\u3001\u8f6f\u7ec4\u7ec7\u6216\u9aa8\u9abc\u611f\u67d3\uff0870%\uff09\u3002\u4e8b\u5b9e\u8bc1\u660e\uff0c\u963f\u7c73\u5361\u661f\u5bf9\u8010\u5e86\u5927\u9709\u7d20\u7684\u75c5\u539f\u4f53\u4e5f\u5f88\u6709\u6548\uff0c\u5bf9\u8fd9\u4e9b\u7ec6\u83cc\u9020\u6210\u7684\u611f\u67d3\u6709 88% \u7684\u6210\u529f\u7387\u3002<\/p>\n\n

\u6807\u51c6\u5242\u91cf\u4e3a\u6bcf\u516c\u65a4 7.5 \u6beb\u514b\uff0c\u6bcf 12 \u5c0f\u65f6\u808c\u8089\u6ce8\u5c04\u4e00\u6b21\u3002\u5bf9\u4e8e\u80be\u529f\u80fd\u4e0d\u5168\u7684\u60a3\u8005\uff0c\u5242\u91cf\u4f1a\u6709\u6240\u8c03\u6574\uff0c\u4ee5\u9632\u6b62\u836f\u7269\u84c4\u79ef\u5f15\u8d77\u5e76\u53d1\u75c7\u3002<\/p>\n\n

\"阿米卡星\"<\/figure>\n\n

\u963f\u7c73\u5361\u661f\u548c\u6297\u751f\u7d20\u8010\u836f\u6027<\/h2>\n\n

\u4f7f\u7528\u963f\u7c73\u5361\u661f\u6700\u5173\u952e\u7684\u4e00\u70b9\u662f\u5b83\u5728\u6297\u51fb\u6297\u751f\u7d20\u8010\u836f\u6027\u65b9\u9762\u7684\u4f5c\u7528\u3002\u8fd9\u79cd\u6297\u751f\u7d20\u5728\u8bb8\u591a\u5176\u4ed6\u836f\u7269\u5931\u6548\u7684\u60c5\u51b5\u4e0b\u4f9d\u7136\u6709\u6548\uff0c\u5c24\u5176\u662f\u5728\u5bf9\u4ed8\u5047\u5355\u80de\u83cc\u548c\u514b\u96f7\u4f2f\u6c0f\u83cc\u7b49\u8010\u836f\u9769\u5170\u6c0f\u9634\u6027\u83cc\u65f6\u3002<\/p>\n\n

\u94dc\u7eff\u5047\u5355\u80de\u83cc\u5bf9\u67d0\u4e9b\u6297\u751f\u7d20\u7c7b\u522b\u7684\u8010\u836f\u7387\u4ecd\u7136\u5f88\u9ad8\u3002\u4f8b\u5982\uff0c2022\u5e74\uff0c24.1%\u7684\u94dc\u7eff\u5047\u5355\u80de\u83cc\u5206\u79bb\u682a\u5bf9\u54cc\u62c9\u897f\u6797-\u4ed6\u5511\u5df4\u5766\u4ea7\u751f\u8010\u836f\u6027\uff0c19.0%\u5bf9\u5934\u5b62\u4ed6\u5576\u4ea7\u751f\u8010\u836f\u6027\uff0c16.4%\u5bf9\u4e9a\u80fa\u57f9\u5357\u548c\u7f8e\u7f57\u57f9\u5357\u7b49\u78b3\u9752\u9709\u70ef\u7c7b\u4ea7\u751f\u8010\u836f\u6027\u3002\u5c3d\u7ba1\u5982\u6b64\uff0c\u5305\u62ec\u963f\u7c73\u5361\u661f\u5728\u5185\u7684\u6c28\u57fa\u7cd6\u82f7\u7c7b\u836f\u7269\u7684\u8010\u836f\u6027\u4ecd\u4fdd\u6301\u5728\u6700\u4f4e\u6c34\u5e73\uff084.0%\uff09\uff0c\u56e0\u6b64\u5728\u8bb8\u591a\u60c5\u51b5\u4e0b\u4ecd\u662f\u4e00\u79cd\u6709\u6548\u7684\u9009\u62e9\u3002\u4e0d\u8fc7\uff0c\u4e3a\u4e86\u9632\u6b62\u963f\u7c73\u5361\u661f\u4e5f\u5931\u53bb\u7597\u6548\uff0c\u8c28\u614e\u4f7f\u7528\u8fd9\u79cd\u836f\u7269\u81f3\u5173\u91cd\u8981\u3002<\/p>\n\n

\u94dc\u7eff\u5047\u5355\u80de\u83cc\u4e0e\u6297\u751f\u7d20\u8010\u836f\u6027<\/h2>\n\n

\u9769\u5170\u6c0f\u9634\u6027\u83cc\uff1a\u94dc\u7eff\u5047\u5355\u80de\u83cc\u7684\u6297\u751f\u7d20\u8010\u836f\u6027\u6982\u51b5\uff0c\u610f\u5927\u5229 2022 \u5e74<\/p>\n\n

\u6297\u751f\u7d20\u7c7b\u522b<\/td>\u6297\u751f\u7d20<\/td>\u9694\u79bb (n)<\/td>R (%)<\/strong><\/strong><\/td>95% IC R (%)<\/strong><\/strong><\/td><\/tr><\/thead>
\u9752\u9709\u7d20\u7c7b<\/td>\u54cc\u62c9\u897f\u6797-\u4ed6\u5511\u5df4\u5766<\/td>5.893<\/td>24,1<\/td>23,0 – 25,2<\/td><\/tr>
\u4e09\u4ee3\/\u56db\u4ee3\u5934\u5b62\u83cc\u7d20<\/td>\u5934\u5b62\u5511\u809f<\/td>5.903<\/td>19,0<\/td>18,0 – 20,0<\/td><\/tr>
\u5934\u5b62\u5421\u809f<\/td>5.775<\/td>17,5<\/td>16,5 – 18,5<\/td><\/tr>
\u5934\u5b62\u5511\u809f\/\u963f\u7ef4\u5df4\u5766<\/td>3.726<\/td>6,0<\/td>5,2 – 6,8<\/td><\/tr>
\u5934\u5b62\u5511\u70f7\/\u4ed6\u5511\u5df4\u5766<\/td>3.322<\/td>5,5<\/td>4,7 – 6,3<\/td><\/tr>
\u5361\u5df4\u57f9\u7c73<\/td>\u4e9a\u80fa\u57f9\u5357<\/td>5.019<\/td>17,7<\/td>16,6 – 18,8<\/td><\/tr>
\u7f8e\u7f57\u57f9\u5357<\/td>5.816<\/td>9,5<\/td>8,7 – 10,3<\/td><\/tr>
\u6c28\u57fa\u7cd6\u82f7\u7c7b<\/td>\u963f\u7c73\u5361\u5947\u7eb3<\/td>5.855<\/td>2,7<\/td>2,3 – 3,1<\/td><\/tr>
\u5e86\u5927\u9709\u7d20<\/td>818<\/td>12,6<\/td>10,4 – 15,1<\/td><\/tr>
\u59a5\u5e03\u9709\u7d20<\/td>3.248<\/td>6,9<\/td>6,0 \u2013 7,8<\/td><\/tr>
\u6c1f\u55b9\u8bfa\u916e\u7c7b<\/td>\u73af\u4e19\u6c99\u661f<\/td>5.943<\/td>16,2<\/td>15,3 – 17,2<\/td><\/tr>
\u5de6\u6c27\u6c1f\u6c99\u661f<\/td>1.874<\/td>21,1<\/td>19,3 – 23,1<\/td><\/tr><\/tbody><\/table><\/figure>\n\n

R=\u963b\u529b\uff1bCI=\u7f6e\u4fe1\u533a\u95f4<\/p>\n\n

\u4ece2015\u5e74\u52302022\u5e74\uff0c\u94dc\u7eff\u5047\u5355\u80de\u83cc\u5206\u79bb\u7269\u5bf9\u7528\u4e8e\u6cbb\u7597\u8fd9\u4e9b\u4fb5\u88ad\u6027\u611f\u67d3\u7684\u4e3b\u8981\u6297\u751f\u7d20\u7c7b\u522b\u4ea7\u751f\u8010\u836f\u6027\u7684\u767e\u5206\u6bd4\u5448\u4e0b\u964d\u8d8b\u52bf\u3002\u7279\u522b\u662f\u81ea2017\u5e74\u4ee5\u6765\uff0c\u5bf9\u6c28\u57fa\u7cd6\u82f7\u7c7b\uff08\u5982\u963f\u7c73\u5361\u661f\uff09\u548c\u6c1f\u55b9\u8bfa\u916e\u7c7b\u836f\u7269\u7684\u8010\u836f\u6027\u6301\u7eed\u4e0b\u964d\u3002\u7136\u800c\uff0c\u5934\u5b62\u4ed6\u5576\u548c\u54cc\u62c9\u897f\u6797-\u4ed6\u5511\u5df4\u5766\u7b49\u5176\u4ed6\u7c7b\u836f\u7269\u7684\u8010\u836f\u6027\u5219\u4fdd\u6301\u76f8\u5bf9\u7a33\u5b9a\u3002\u78b3\u9752\u9709\u70ef\u7c7b\u836f\u7269\u7684\u8010\u836f\u6027\u5728\u524d\u4e24\u5e74\u6709\u6240\u4e0a\u5347\uff0c2022 \u5e74\u5219\u7565\u6709\u4e0b\u964d\u3002<\/p>\n\n

\"\"<\/figure>\n\n

\u94dc\u7eff\u5047\u5355\u80de\u83cc\u5bf9\u54cc\u62c9\u897f\u6797-\u4ed6\u5511\u5df4\u5766\u3001\u5934\u5b62\u4ed6\u5576\u3001\u78b3\u9752\u9709\u70ef\u7c7b\u3001\u6c28\u57fa\u7cd6\u82f7\u7c7b\u548c\u6c1f\u55b9\u8bfa\u916e\u7c7b\u836f\u7269\u7684\u8010\u836f\u6027\u767e\u5206\u6bd4\uff08\u610f\u5927\u5229\uff0c2015-2022 \u5e74\uff09<\/p>\n\n

\u5982\u4e0a\u56fe\u6240\u793a\uff0c2022 \u5e74\uff0c\u94dc\u7eff\u5047\u5355\u80de\u83cc\u5bf9\u54cc\u62c9\u897f\u6797-\u4ed6\u5511\u5df4\u5766\u7684\u8010\u836f\u7387\u6700\u9ad8\uff0824.1%\uff09\uff0c\u5176\u6b21\u662f\u5934\u5b62\u5511\u809f\uff0819.0%\uff09\u3001\u6c1f\u55b9\u8bfa\u916e\u7c7b\uff08\u5982\u73af\u4e19\u6c99\u661f\u548c\u5de6\u6c27\u6c1f\u6c99\u661f\uff09\uff0818.5%\uff09\u3001\u78b3\u9752\u9709\u70ef\u7c7b\uff08\u5982\u4e9a\u80fa\u57f9\u5357\u548c\u7f8e\u7f57\u57f9\u5357\uff09\uff0816\u3001 0%\uff09\u3001\u6c1f\u55b9\u8bfa\u916e\u7c7b\uff08\u5982\u73af\u4e19\u6c99\u661f\u548c\u5de6\u6c27\u6c1f\u6c99\u661f\uff09\uff0818.5%\uff09\u3001\u78b3\u9752\u9709\u70ef\u7c7b\uff08\u5982\u4e9a\u80fa\u57f9\u5357\u548c\u7f8e\u7f57\u57f9\u5357\uff09\uff0816.4%\uff09\u548c\u6c28\u57fa\u7cd6\u82f7\u7c7b\uff08\u963f\u7c73\u5361\u661f\u548c\u5e86\u5927\u9709\u7d20\u7684\u8010\u836f\u7387\u4f4e\u81f3 4.0%\uff09\u3002\u8fd9\u4e00\u6570\u5b57\u8bc1\u5b9e\u4e86\u963f\u7c73\u5361\u661f\u5bf9\u8010\u836f\u7ec6\u83cc\u83cc\u682a\u7684\u6301\u7eed\u7597\u6548\uff0c\u7a81\u51fa\u8868\u660e\u963f\u7c73\u5361\u661f\u9632\u6cbb\u4e25\u91cd\u611f\u67d3\uff0c\u7279\u522b\u662f\u7531\u94dc\u7eff\u5047\u5355\u80de\u83cc\u7b49\u591a\u91cd\u8010\u836f\u75c5\u539f\u4f53\u5f15\u8d77\u7684\u611f\u67d3\u7684\u80fd\u529b\u4ecd\u7136\u975e\u5e38\u91cd\u8981\u3002<\/p>\n\n

\u60c5\u5883\u8bbe\u8ba1\uff1a<\/p>\n\n

Pseudomonas aeruginosa – Sorveglianza dell\u2019Antibiotico-Resistenza – AR-ISS<\/a><\/p>\n\n

A review of results of clinical trials with amikacin – PubMed (nih.gov)<\/a><\/p>\n\n

<\/p>\n","protected":false},"excerpt":{"rendered":"

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